Dr. med Markus Bock (MD)
Affiliation:
- Department of Hand Surgery, Upper Extremity and Foot Surgery, Center for Orthopedics, Rheumatoid Arthritis and Trauma Surgery, Hospital Waldfriede, Argentinische Allee 40, 14163, Berlin, Germany.
- Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Germany.
- Clinic of Endocrinology, Diabetes and Nutrition, Endocrine Tumor Center, Metabolic Research Unit, Charité – Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany
Clinical Experience:
2022
Head of MVZ Waldfriede gGmbH, Fischerhüttenstr. 111, 14163 Berlin, Germany. Focus on Rheumatology, Neuroimmunology, Hand Surgery and Dietetics.
2017-2021
Attending physician at the department of Rheumatology, Ernst von Bergmann Hospital, Charlottenstraße 72, 14467 Potsdam, Germany.
Attending physician at the Department of Hand Surgery, Upper Extremity and Foot Surgery, Center for Rheumatoid Arthritis Surgery, Hospital Waldfriede, Argentinische Allee 40, 14163 Berlin, Germany.
Attending physician at the Practice of Rheumatology ‘Rheumahaus’, Friedrich Ebert Straße 35 14469 Potsdam, Germany.
2013-2016
Attending physician at the outpatient clinics of Lipidology/Gastro-/Hepatology (Prof. Dr. Dr. med. Karsten Weylandt).
2011-2016
Attending physician at the outpatient clinics of Neuro-immunology and NeuroCure Clinical Research Center (NCRC) (Prof. Dr. med. Friedemann Paul).
2007 – 2010
Doctoral student of the Charité at the Neuroscientific Research Center (NWFZ) (Prof. Dr. Frauke Zipp)
Research experience:
2011 – 2023 involved in following clinical trials:
1. Position: PI: Ketogenic Diet and Caloric Restriction in Multiple sclerosis (investigator initiated Trial); ClinicalTrials.gov Identifier:
a) NCT01538355 (PI)
b) NCT03508414 (PI)
c) Ultrasound therapy in Rhizarthrosis: NCT04115085 (PI)
2. Position: SI; Purpose: Metabolic Effects of a Green Tea Extract in Multiple Sclerosis Patients investigator initiated Trial; ClinicalTrials.gov Identifier: NCT01417312;
3. Position: SI, Purpose: Heart failure, Eudract Nr. 2009-015834-31; Phase: III
4. Position: SI, Purpose: Diabetes mellitus II, Eudract Nr. 2012-004096-38; Phase: III
5. Position: SI, Purpose: ANCA, Eudract Nr. 2011-001222-15; Phase: II
6. Position: SI, Purpose: CCR2-Antagonist, Eudract Nr. 2011-001267-49; Phase: II
7. Position: SI, Purpose: cardiovascular death, heart failure, Eudract Nr. 2013-001747-31; Phase: III
2007-2011 involved in following clinical trials at NWFZ and NCRC (supervision Prof. Zipp and Prof. Paul)
8. Position: SI, Purpose: Epigallocatechin-Gallat in relapsing remittent multiple sclerosis, Study name: SuniMS; Phase: II
9. Position: SI, Purpose: Epigallocatechin-Gallat in progressive forms of multiple sclerosis, Study name: SPREMES; Phase: II
10. Position: SI, Purpose: Flupirtin as an oral therapy in progressive multiple sclerosis, Study name: FLORIMS; Phase: II
Education:
2013 thesis defense. Title of thesis: “Quantification of neurodegeneration In multiple sclerosis patients by optical coherence tomography in Dependence to visual function”. Predicate: magna cum laude
2011 licensed physician
2005-2011 Medical study Charité-Universitätsmedizin Berlin
Research direction:
Implementation of metabolism enhancing interventions in patients with inflammatory disorders. Implementation of imaging techniques
Original research:
Bock M, Steffen F, Zipp F, Bittner S. Impact of dietary intervention on serum neurofilament light chain in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2022; 9(1):e1102
Bahr*, L. S.; Bock*, M.; Liebscher, D.; Bellmann-Strobl, J.; Franz, L.; Prüß, A.; Schumann, D.; Piper, S. K.; Kessler, C. S.; Steckhan, N.; Michalsen, A.; Paul, F.; Mähler, A. Ketogenic Diet and Fasting Diet as Nutritional Approaches in Multiple Sclerosis (NAMS): Protocol of a Randomized Controlled Study. Trials 2020, 21 (1), 3. https://doi.org/10.1186/s13063-019-3928-9.
Bock, M.; Karber, M.; Kuhn, H. Ketogenic Diets Attenuate Cyclooxygenase and Lipoxygenase Gene Expression in Multiple Sclerosis. EBioMedicine 2018, 36, 293–303. https://doi.org/10.1016/j.ebiom.2018.08.057.
Bock, M.; Michalsen, A.; Paul, F. Ketogenic Diet and Prolonged Fasting Improve Health Related Quality of Life and Blood Lipid Profile in Multiple Sclerosis – a Randomized Controlled Trial. ECTRIMS Online Library 2015, 116359, P1509.
Choi, I. Y.; Piccio, L.; Childress, P.; Bollman, B.; Ghosh, A.; Brandhorst, S.; Suarez, J.; Michalsen, A.; Cross, A. H.; Morgan, T. E.; Wei, M.; Paul, F.; Bock*, M.; Longo*, V. D. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep 2016, 15 (10), 2136–2146. https://doi.org/10.1016/j.celrep.2016.05.009.
Swidsinski, A.; Dörffel, Y.; Loening-Baucke, V.; Gille, C.; Göktas, Ö.; Reißhauer, A.; Neuhaus, J.; Weylandt, K.-H.; Guschin, A.; Bock, M. Reduced Mass and Diversity of the Colonic Microbiome in Patients with Multiple Sclerosis and Their Improvement with Ketogenic Diet. Front. Microbiol. 2017, 8. https://doi.org/10.3389/fmicb.2017.01141.
Gonder, U.; von Schacky, C.; Worm, N.; Lechner, B.; Bock, M.; Lechner, K. [Dementia and Metabolic-Vascular Risk Factors: Strategies for Prevention]. Dtsch. Med. Wochenschr. 2019, 144 (17), 1212–1217. https://doi.org/10.1055/a-0940-5452.
Bock, M.; Brandt, A. U.; Dörr, J.; Kraft, H.; Weinges-Evers, N.; Gaede, G.; Pfueller, C. F.; Herges, K.; Radbruch, H.; Ohlraun, S.; Bellmann-Strobl, J.; Kuchenbecker, J.; Zipp, F.; Paul, F. Patterns of Retinal Nerve Fiber Layer Loss in Multiple Sclerosis Patients with or without Optic Neuritis and Glaucoma Patients. Clin Neurol Neurosurg 2010, 112 (8), 647–652. https://doi.org/10.1016/j.clineuro.2010.04.014.
Bock, M.; Brandt, A. U.; Dörr, J.; Pfueller, C. F.; Ohlraun, S.; Zipp, F.; Paul, F. Time Domain and Spectral Domain Optical Coherence Tomography in Multiple Sclerosis: A Comparative Cross-Sectional Study. Mult. Scler. 2010, 16 (7), 893–896. https://doi.org/10.1177/1352458510365156.
Bock, M.; Paul, F.; Dörr, J. [Diagnosis and monitoring of multiple sclerosis: the value of optical coherence tomography]. Nervenarzt 2013, 84 (4), 483–492. https://doi.org/10.1007/s00115-012-3707-2.
Bock, M.; Brandt, A. U.; Kuchenbecker, J.; Dörr, J.; Pfueller, C. F.; Weinges-Evers, N.; Gaede, G.; Zimmermann, H.; Bellmann-Strobl, J.; Ohlraun, S.; Zipp, F.; Paul, F. Impairment of Contrast Visual Acuity as a Functional Correlate of Retinal Nerve Fibre Layer Thinning and Total Macular Volume Reduction in Multiple Sclerosis. Br J Ophthalmol 2012, 96 (1), 62–67. https://doi.org/10.1136/bjo.2010.193581.
Dörr, J.; Radbruch, H.; Bock, M.; Wuerfel, J.; Brüggemann, A.; Wandinger, K. P.; Zeise, D.; Pfueller, C. F.; Zipp, F.; Paul, F. Encephalopathy, Visual Disturbance and Hearing Loss-Recognizing the Symptoms of Susac Syndrome. Nat Rev Neurol 2009, 5 (12), 683–688. https://doi.org/10.1038/nrneurol.2009.176.
Dörr, J.; Wernecke, K. D.; Bock, M.; Gaede, G.; Wuerfel, J. T.; Pfueller, C. F.; Bellmann-Strobl, J.; Freing, A.; Brandt, A. U.; Friedemann, P. Association of Retinal and Macular Damage with Brain Atrophy in Multiple Sclerosis. PLoS ONE 2011, 6 (4), e18132. https://doi.org/10.1371/journal.pone.0018132.
Mähler, A.; Steiniger, J.; Bock, M.; Brandt, A. U.; Haas, V.; Boschmann, M.; Paul, F. Is Metabolic Flexibility Altered in Multiple Sclerosis Patients? PLoS ONE 2012, 7 (8), e43675. https://doi.org/10.1371/journal.pone.0043675.
Mähler, A.; Steiniger, J.; Bock, M.; Klug, L.; Parreidt, N.; Lorenz, M.; Zimmermann, B. F.; Krannich, A.; Paul, F.; Boschmann, M. Metabolic Response to Epigallocatechin-3-Gallate in Relapsing-Remitting Multiple Sclerosis: A Randomized Clinical Trial. Am. J. Clin. Nutr. 2015, 101 (3), 487–495. https://doi.org/10.3945/ajcn.113.075309.
Mossakowski, A. A.; Pohlan, J.; Bremer, D.; Lindquist, R.; Millward, J. M.; Bock, M.; Pollok, K.; Mothes, R.; Viohl, L.; Radbruch, M.; Gerhard, J.; Bellmann-Strobl, J.; Behrens, J.; Infante-Duarte, C.; Mähler, A.; Boschmann, M.; Rinnenthal, J. L.; Füchtemeier, M.; Herz, J.; Pache, F. C.; Bardua, M.; Priller, J.; Hauser, A. E.; Paul, F.; Niesner, R.; Radbruch, H. Tracking CNS and Systemic Sources of Oxidative Stress during the Course of Chronic Neuroinflammation. Acta Neuropathologica 2015, 130 (6), 799–814. https://doi.org/10.1007/s00401-015-1497-x.
Pfueller, C. F.; Brandt, A. U.; Schubert, F.; Bock, M.; Walaszek, B.; Waiczies, H.; Schwenteck, T.; Dörr, J.; Bellmann-Strobl, J.; Mohr, C.; Weinges-Evers, N.; Ittermann, B.; Wuerfel, J. T.; Paul, F. Metabolic Changes in the Visual Cortex Are Linked to Retinal Nerve Fiber Layer Thinning in Multiple Sclerosis. PLoS ONE 2011, 6 (4), e18019. https://doi.org/10.1371/journal.pone.0018019.
Urbanek, C.; Weinges-Evers, N.; Bellmann-Strobl, J.; Bock, M.; Dörr, J.; Hahn, E.; Neuhaus, A. H.; Opgen-Rhein, C.; Ta, T. M. T.; Herges, K.; Pfueller, C. F.; Radbruch, H.; Wernecke, K. D.; Ohlraun, S.; Zipp, F.; Dettling, M.; Paul, F. Attention Network Test Reveals Alerting Network Dysfunction in Multiple Sclerosis. Mult Scler 2010, 16 (1), 93–99. https://doi.org/10.1177/1352458509350308.
Weinges-Evers, N.; Brandt, A. U.; Bock, M.; Pfueller, C. F.; Dörr, J.; Bellmann-Strobl, J.; Scherer, P.; Urbanek, C.; Boers, C.; Ohlraun, S.; Zipp, F.; Paul, F. Correlation of Self-Assessed Fatigue and Alertness in Multiple Sclerosis. Mult Scler 2010, 16 (9), 1134–1140. https://doi.org/10.1177/1352458510374202.
Zimmermann, H.; Freing, A.; Kaufhold, F.; Gaede, G.; Bohn, E.; Bock, M.; Oberwahrenbrock, T.; Young, K.-L.; Dörr, J.; Wuerfel, J. T.; Schippling, S.; Paul, F.; Brandt, A. U. Optic Neuritis Interferes with Optical Coherence Tomography and Magnetic Resonance Imaging Correlations. Mult. Scler. 2013, 19 (4), 443–450. https://doi.org/10.1177/1352458512457844.
